{"created":"2023-06-19T06:56:51.426482+00:00","id":183,"links":{},"metadata":{"_buckets":{"deposit":"165de944-7f0d-41c7-a7ac-43486b3363c2"},"_deposit":{"created_by":13,"id":"183","owners":[13],"pid":{"revision_id":0,"type":"depid","value":"183"},"status":"published"},"_oai":{"id":"oai:rctoyota.repo.nii.ac.jp:00000183","sets":["1"]},"author_link":["305","364","365","366","367","364","369","366","367"],"control_number":"183","item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2015-06","subitem_date_issued_type":"Issued"}]},"item_10007_description_10":{"attribute_name":"研究代表者番号","attribute_value_mlt":[{"subitem_description":"90399030","subitem_description_type":"Other"}]},"item_10007_description_11":{"attribute_name":"研究機関","attribute_value_mlt":[{"subitem_description":"日本赤十字豊田看護大学","subitem_description_type":"Other"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"神経芽腫細胞株では、神経突起様の形態を示すN-typeと、平たく広い細胞質を示すS-typeの形態が認められ、相互に形態変化を示す現象（transconversion）が知られる。細胞株SK-N-SHで表面マーカーを検討した結果、transconversionを反映する表面マーカーの相互変化が観察された。相互変化を示す細胞集団から、変化しない固定した分画が生じるが、この分画は増殖が速く、N-typeの形態を示し、相互変化する細胞集団よりもマーカー上、分化の下位に相当するものと考えられた。神経芽腫細胞株においては、生理的な神経堤細胞の分化にみられる明らかなピラミッド型の階層は見出されなかった。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"In neuroblastoma cell lines, morphological transconversion between cells with neuronal process (N-type) and flat cells (S-type) are observed. Transconversion of cell surface markers correlating with morphological changes and differentiation of neuroblastoma cells were found. From　several transconverting cell fractions, a cell population with a fixed combination of cell surface markers was derived. This population was morphologically N-type with rapid proliferation. It was suggested that this population forms a lower rank of differention than transconverting cell populations from the view point of cell surface markers. A definite hierarchy like developmental process of neural crest cell differentiation was not observed in neuroblastoma.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"Application/PDF","subitem_description_type":"Other"}]},"item_10007_description_4":{"attribute_name":"研究代表者ID","attribute_value_mlt":[{"subitem_description":"90399030","subitem_description_type":"Other"}]},"item_10007_description_7":{"attribute_name":"研究分担者ID","attribute_value_mlt":[{"subitem_description":"00283432","subitem_description_type":"Other"},{"subitem_description":"90303619","subitem_description_type":"Other"},{"subitem_description":"40144141","subitem_description_type":"Other"},{"subitem_description":"40432273","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"24590434","subitem_description_type":"Other"}]},"item_10007_heading_23":{"attribute_name":"見出し","attribute_value_mlt":[{"subitem_heading_banner_headline":"2012年度～2014年度　科学研究費助成事業（基盤研究(C)）研究成果報告書","subitem_heading_language":"ja"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"KAKEN"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/d/p/24590434.ja.html","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1690424982431":{"attribute_name":"研究分担者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"IWASHITA, Toshihide","creatorNameLang":"en"},{"creatorName":"岩下, 寿秀","creatorNameLang":"ja"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"村上, 秀樹","creatorNameLang":"ja"},{"creatorName":"MURAKAMI, Hideki","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"SAGA, Shinsuke","creatorNameLang":"en"},{"creatorName":"佐賀, 信介","creatorNameLang":"ja"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"TAKAHASHI, Yoshiyuki","creatorNameLang":"en"},{"creatorName":"髙橋, 義行","creatorNameLang":"ja"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-07-31"}],"displaytype":"detail","filename":"研究成果報告書　黒川先生.pdf","filesize":[{"value":"433.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"交感神経系神経堤幹細胞及び神経芽腫幹細胞の分離同定と分化階層の解析","url":"https://rctoyota.repo.nii.ac.jp/record/183/files/研究成果報告書　黒川先生.pdf"},"version_id":"06b47165-c5b9-4be3-96b3-01b158ae0e4a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"神経芽細胞腫","subitem_subject_scheme":"Other"},{"subitem_subject":"表面マーカー","subitem_subject_scheme":"Other"},{"subitem_subject":"幹細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"副腎髄質","subitem_subject_scheme":"Other"},{"subitem_subject":"腫瘍幹細胞","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"黒川, 景","creatorNameLang":"ja"},{"creatorName":"KUROKAWA Kei","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{},{}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"交感神経系神経堤幹細胞及び神経芽腫幹細胞の分離同定と分化階層の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"交感神経系神経堤幹細胞及び神経芽腫幹細胞の分離同定と分化階層の解析","subitem_title_language":"ja"},{"subitem_title":"Identification and analysis of the stem cells and its differentiation in sympathetic neural crest cells and neuroblastoma cells","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"13","path":["1"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-07-31"},"publish_date":"2015-07-31","publish_status":"0","recid":"183","relation_version_is_last":true,"title":["交感神経系神経堤幹細胞及び神経芽腫幹細胞の分離同定と分化階層の解析"],"weko_creator_id":"13","weko_shared_id":-1},"updated":"2023-07-27T04:16:33.201556+00:00"}