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交感神経系神経堤幹細胞及び神経芽腫幹細胞の分離同定と分化階層の解析
https://rctoyota.repo.nii.ac.jp/records/183
https://rctoyota.repo.nii.ac.jp/records/183c317a5b8-aeef-44be-9811-741f926a89e6
名前 / ファイル | ライセンス | アクション |
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交感神経系神経堤幹細胞及び神経芽腫幹細胞の分離同定と分化階層の解析 (433.4 kB)
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Item type | 報告書 / Research Paper(1) | |||||||||
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公開日 | 2015-07-31 | |||||||||
タイトル | ||||||||||
言語 | ja | |||||||||
タイトル | 交感神経系神経堤幹細胞及び神経芽腫幹細胞の分離同定と分化階層の解析 | |||||||||
タイトル | ||||||||||
言語 | en | |||||||||
タイトル | Identification and analysis of the stem cells and its differentiation in sympathetic neural crest cells and neuroblastoma cells | |||||||||
言語 | ||||||||||
言語 | jpn | |||||||||
キーワード | ||||||||||
主題Scheme | Other | |||||||||
主題 | 神経芽細胞腫 | |||||||||
キーワード | ||||||||||
主題Scheme | Other | |||||||||
主題 | 表面マーカー | |||||||||
キーワード | ||||||||||
主題Scheme | Other | |||||||||
主題 | 幹細胞 | |||||||||
キーワード | ||||||||||
主題Scheme | Other | |||||||||
主題 | 副腎髄質 | |||||||||
キーワード | ||||||||||
主題Scheme | Other | |||||||||
主題 | 腫瘍幹細胞 | |||||||||
資源タイプ | ||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||||||
資源タイプ | research report | |||||||||
研究代表者 |
黒川, 景
× 黒川, 景
WEKO
305
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研究代表者ID | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | 90399030 | |||||||||
研究分担者 |
岩下, 寿秀
× 岩下, 寿秀× 村上, 秀樹× 佐賀, 信介× 髙橋, 義行 |
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内容記述タイプ | Other | |||||||||
内容記述 | 00283432 | |||||||||
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内容記述タイプ | Other | |||||||||
内容記述 | 90303619 | |||||||||
研究分担者ID | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | 40144141 | |||||||||
研究分担者ID | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | 40432273 | |||||||||
報告年度 | ||||||||||
日付 | 2015-06 | |||||||||
日付タイプ | Issued | |||||||||
研究課題番号 | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | 24590434 | |||||||||
研究代表者番号 | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | 90399030 | |||||||||
研究機関 | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | 日本赤十字豊田看護大学 | |||||||||
抄録 | ||||||||||
内容記述タイプ | Abstract | |||||||||
内容記述 | 神経芽腫細胞株では、神経突起様の形態を示すN-typeと、平たく広い細胞質を示すS-typeの形態が認められ、相互に形態変化を示す現象(transconversion)が知られる。細胞株SK-N-SHで表面マーカーを検討した結果、transconversionを反映する表面マーカーの相互変化が観察された。相互変化を示す細胞集団から、変化しない固定した分画が生じるが、この分画は増殖が速く、N-typeの形態を示し、相互変化する細胞集団よりもマーカー上、分化の下位に相当するものと考えられた。神経芽腫細胞株においては、生理的な神経堤細胞の分化にみられる明らかなピラミッド型の階層は見出されなかった。 | |||||||||
言語 | ja | |||||||||
抄録 | ||||||||||
内容記述タイプ | Abstract | |||||||||
内容記述 | In neuroblastoma cell lines, morphological transconversion between cells with neuronal process (N-type) and flat cells (S-type) are observed. Transconversion of cell surface markers correlating with morphological changes and differentiation of neuroblastoma cells were found. From several transconverting cell fractions, a cell population with a fixed combination of cell surface markers was derived. This population was morphologically N-type with rapid proliferation. It was suggested that this population forms a lower rank of differention than transconverting cell populations from the view point of cell surface markers. A definite hierarchy like developmental process of neural crest cell differentiation was not observed in neuroblastoma. | |||||||||
言語 | en | |||||||||
関連サイト | ||||||||||
識別子タイプ | URI | |||||||||
関連識別子 | https://kaken.nii.ac.jp/d/p/24590434.ja.html | |||||||||
関連名称 | KAKEN | |||||||||
フォーマット | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | Application/PDF | |||||||||
著者版フラグ | ||||||||||
出版タイプ | AM | |||||||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
見出し | ||||||||||
大見出し | 2012年度~2014年度 科学研究費助成事業(基盤研究(C))研究成果報告書 | |||||||||
言語 | ja |